Indiana never trailed and limited the Bulls to 25.9 percent shooting (7 of 27) from 3-point range. The Pacers had struggled defensively during the four-game skid, allowing an average of 115 points.
Thaddeus Young chipped in 13 points for Indiana (6-7), which won for the first time since Nov. 1. Myles Turner also reached double figures for the Pacers and finished with 11 points and nine rebounds. Cory Joseph rounded out the Indiana scoring attack with 10 points.
Bobby Portis, playing his second game since returning from an eight-game suspension, scored 20 points and grabbed 11 rebounds off the bench to lead Chicago (2-8), which lost its third straight.
Kris Dunn scored 16 points for Chicago, which also got 14 points from Justin Holiday and 12 points from rookie Lauri Markkanen, who reached double figures for the 10th straight game.
The Pacers led by as many as 24 points in the fourth quarter and maintained a double-digit lead as Indiana shot 51.2 percent from the field and connected on 12 of 29 from 3-point range.
Indiana led 45-35 at halftime.
NOTES: Pacers F/C Domantas Sabonis returned after missing Indiana's last two games with a right calf contusion. ... F Glenn Robinson III (ankle sprain) and F Alex Poythress were inactive for Indiana. ... Bulls F David Nwaba (right ankle sprain) remains out. ... Bulls president Michael Reinsdorf gave coach Fred Hoiberg a vote of confidence, saying despite the Bulls' slow start that Hoiberg's efforts to get his team to play the right way isn't "going unnoticed." "Right now, we're happy," Reinsdorf said. "The team is playing really hard. Fred's got them playing really hard." ... The NBA announced that Chicago will host the 2020 All-Star Game. The city last hosted the event in 1988 at Chicago Stadium. ... NBA commissioner Adam Silver attended Friday's game after making the All-Star announcement earlier in the day.