Chicago halted a three-game skid and claimed its first home victory in eight starts at their suburban Allstate Arena home.
The Sky (4-12) used a dominant third quarter to open a 21-point lead and never saw their advantage fall below 12 points midway through the fourth quarter before they pulled away at the end.
Courtney Vandersloot led a balanced attack with 26 points. Tamera Young and Cheyenne Parker scored 18 and 14 points, respectively. Stefanie Dolson had 12 and Allie Quigley added 11.
Rebekkah Brunson scored 22 points for the Lynx (13-2), whose four-game winning streak ended. Sylvia Fowles had 13 points and Seimone Augustus added 10.
The Sky led 31-26 after one quarter and 54-47 at halftime. They expanded the margin to 21 points at 76-55 after a Keisha Hampton putback with 33 seconds left in the third quarter.
Minnesota's Lindsay Whalen made two free throws with 18 seconds left in the third quarter to trim the Lynx deficit to 19 entering the fourth quarter.
The Lynx crept within 12 points at 79-67 on a Brunson 3-pointer with 7:49 left. But they got no closer as Dolson hit a 3-pointer with 7:37 left for an 82-67 lead. Chicago then pushed the margin past 20 with less than three minutes to play.
Minnesota travels to Phoenix on Friday for its next game. Chicago hosts Dallas in a Wednesday matinee and travels to New York on Friday.